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Exposing the human nude phenotype

Jorge Frank, Claudio Pignata, Andrei A. Panteleyev, David M. Prowse, Howard Baden, Lorin Weiner, Lucia Gaetaniello, Wasim Ahmad, Nicola Pozzi, Peter B. Cserhalmi-Friedman, Vincent M. Aita, Hendrik Uyttendaele, Derek Gordon, Jurg Ott, Janice L. Brissette and Angela M. Christiano ()
Additional contact information
Jorge Frank: Columbia University
Claudio Pignata: Unit of Immunology, Federico II University
Andrei A. Panteleyev: Columbia University
David M. Prowse: Harvard Medical School
Howard Baden: Harvard Medical School
Lorin Weiner: Harvard Medical School
Lucia Gaetaniello: Unit of Immunology, Federico II University
Wasim Ahmad: Columbia University
Nicola Pozzi: Unit of Immunology, Federico II University
Peter B. Cserhalmi-Friedman: Columbia University
Vincent M. Aita: Genetics and Development, Columbia University
Hendrik Uyttendaele: Columbia University
Derek Gordon: Laboratory of Statistical Genetics, The Rockefeller University
Jurg Ott: Laboratory of Statistical Genetics, The Rockefeller University
Janice L. Brissette: Harvard Medical School
Angela M. Christiano: Columbia University

Nature, 1999, vol. 398, issue 6727, 473-474

Abstract: Abstract The recent discovery of the human counterpart of the hairless mouse phenotype1 has helped our understanding of the molecular genetics of hair growth. But there are no reports of a defect in the human homologue of the best known of the ‘bald’ mouse phenotypes, the nude mouse2. This may be because affected individuals are so gravely ill from the accompanying immunodeficiency that their baldness goes unnoticed. We have carried out a genetic analysis that reveals a human homologue of the nude mouse.

Date: 1999
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DOI: 10.1038/18997

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