Gatekeepers of recombination

James E. Haber ()
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James E. Haber: Brandeis University

Nature, 1999, vol. 398, issue 6729, 665-667

Abstract: There are two main pathways by which chromosomal double-strand breaks are repaired — nonhomologous end-joining and homologous recombination. The 'gatekeeper' for the first of these processes is the Ku protein, and the warden of the second has now been identified as Rad52. The authors propose a model in which Rad52 and Ku compete to channel the broken ends down their respective pathways.

Date: 1999
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DOI: 10.1038/19423

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