Movement of motor and cargo along cilia

Jose T. Orozco, Karen P. Wedaman, Dawn Signor, Heather Brown, Lesilee Rose and Jonathan M. Scholey ()
Additional contact information
Jose T. Orozco: Section of Molecular and Cellular Biology, University of California
Karen P. Wedaman: Section of Molecular and Cellular Biology, University of California
Dawn Signor: Section of Molecular and Cellular Biology, University of California
Heather Brown: Section of Molecular and Cellular Biology, University of California
Lesilee Rose: Section of Molecular and Cellular Biology, University of California
Jonathan M. Scholey: Section of Molecular and Cellular Biology, University of California

Nature, 1999, vol. 398, issue 6729, 674-674

Abstract: Abstract Intraflagellar transport (IFT)1 is important in the formation and maintenance of many cilia, such as the motile cilia that drive the swimming of cells and embryos2, the nodal cilia that generate left-right asymmetry in vertebrate embryos3, and the sensory cilia that detect sensory stimuli in some animals4. The heterotrimeric kinesin-II motor protein drives the anterograde transport of macromolecular complexes, called rafts, along microtubule tracks from the base of the cilium to its distal tip5, whereas cytoplasmic dynein moves the rafts back in the retrograde direction6. We have used fluorescence microscopy to visualize for the first time the intracellular transport of a motor and its cargo in vivo. We observed the anterograde movement of green fluorescent protein (GFP)-labelled kinesin-II motors and IFT rafts within sensory cilia on chemosensory neurons in living Caenorhabditis elegans.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/19448 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:398:y:1999:i:6729:d:10.1038_19448

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/19448

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().