p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development

Annie Yang, Ronen Schweitzer, Deqin Sun, Mourad Kaghad, Nancy Walker, Roderick T. Bronson, Cliff Tabin, Arlene Sharpe, Daniel Caput, Christopher Crum and Frank McKeon ()
Additional contact information
Annie Yang: Departments of Cell Biology
Ronen Schweitzer: Genetics, Harvard Medical School,
Deqin Sun: Brigham and Women's Hospital, Harvard Medical School
Mourad Kaghad: Sanofi Biorecherche,
Nancy Walker: Sanofi Biorecherche,
Roderick T. Bronson: Human Nutrition Research Center on Aging, Tufts University School of Veterinary Medicine
Cliff Tabin: Genetics, Harvard Medical School,
Arlene Sharpe: Immunology Research Division
Daniel Caput: Sanofi Biorecherche,
Christopher Crum: Brigham and Women's Hospital, Harvard Medical School
Frank McKeon: Departments of Cell Biology

Nature, 1999, vol. 398, issue 6729, 714-718

Abstract: Abstract The p63 gene, a homologue of the tumour-suppressor p53 (1–5), is highly expressed in the basal or progenitor layers of many epithelial tissues1. Here we report that mice homozygous for a disrupted p63 gene have major defects in their limb, craniofacial and epithelial development. p63 is expressed in the ectodermal surfaces of the limb buds, branchial arches and epidermal appendages, which are all sites of reciprocal signalling that direct morphogenetic patterning of the underlying mesoderm. The limb truncations are due to a failure to maintain the apical ectodermal ridge, a stratified epithelium, essential for limb development. The embryonic epidermis of p63 −/− mice undergoes an unusual process of non-regenerative differentiation, culminating in a striking absence of all squamous epithelia and their derivatives, including mammary, lacrymal and salivary glands. Taken together, our results indicate that p63 is critical for maintaining the progenitor-cell populations that are necessary to sustain epithelial development and morphogenesis.

Date: 1999
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DOI: 10.1038/19539

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