Legs to wings and back again

Lee Niswander ()
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Lee Niswander: Memorial Sloan Kettering Cancer Center, and the Howard Hughes Medical Institute

Nature, 1999, vol. 398, issue 6730, 751-752

Abstract: How do arms or wings (forelimbs) become different from legs (hindlimbs)? It all hinges on the expression of specific transcription factors in the embryonic fore- or hindlimb buds. Expression of the Tbx5 protein in the chick results in the development of wings, whereas the Tbx4 protein specifies legs. Misexpression of these proteins generates wing-like legs and leg-like wings, respectively, and should tell us much about the mechanisms by which these proteins act.

Date: 1999
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DOI: 10.1038/19625

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