Mitotic treasures in the nucleolus

Jeffrey B. Bachant and Stephen J. Elledge ()
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Jeffrey B. Bachant: Baylor College of Medicine
Stephen J. Elledge: Baylor College of Medicine

Nature, 1999, vol. 398, issue 6730, 757-758

Abstract: How does a cell regulate its exit from the stage of the cell cycle known as mitosis? The answer, surprisingly, involves a new regulatory principle. Exit, it seems, is controlled by switching off mitotic kinases, and this is done by a phosphatase called Cdc14, an inactive form of which is sequestered in the nucleolus until needed. This is the first time that nucleolar localization has been shown as a regulatory mechanism.

Date: 1999
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DOI: 10.1038/19641

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