Tbx5 and Tbx4 genes determine the wing/leg identity of limb buds

Jun K. Takeuchi, Kazuko Koshiba-Takeuchi, Ken Matsumoto, Astrid Vogel-Höpker, Mayumi Naitoh-Matsuo, Keiko Ogura, Naoki Takahashi, Kunio Yasuda and Toshihiko Ogura ()
Additional contact information
Jun K. Takeuchi: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5
Kazuko Koshiba-Takeuchi: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5
Ken Matsumoto: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5
Mayumi Naitoh-Matsuo: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5
Keiko Ogura: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5
Naoki Takahashi: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5
Kunio Yasuda: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5
Toshihiko Ogura: Nara Institute of Science and Technology Graduate School of Biological Sciences 8916-5

Nature, 1999, vol. 398, issue 6730, 810-814

Abstract: Abstract Much progress has been made in understanding limb development1,2,3. Most genes are expressed equally and in the same pattern in the fore- and hindlimbs, which nevertheless develop into distinct structures3,4,5,6,7,8. The T-box genes Tbx5 and Tbx4, on the other hand, are expressed differently in chick wing (Tbx5) and leg (Tbx4) buds9,10,11,12. Molecular analysis of the optomotor blind gene13, which belongs to the same family of transcription factors, has revealed that this gene is involved in the transdetermination of Drosophila wing and leg imaginal discs14. In addition, expression of Tbx5 and Tbx4 correlates well with the identity of ectopic limb buds induced by fibroblast growth factor4,5,15,16,17,18,19. Thus, it is thought that Tbx5 and Tbx4 might be involved in determining limb identity. Another candidate is the Pitx1 gene, which encodes a bicoid-type homeodomain transcription factor that is expressed in leg buds20,21. Here we determine the importance of these factors in establishing limb identity.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/19762 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:398:y:1999:i:6730:d:10.1038_19762

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/19762

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().