A spine to remember

Per Andersen ()
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Per Andersen: Per Andersen is at the Institute for Basic Medical Research, University of Oslo

Nature, 1999, vol. 399, issue 6731, 19-20

Abstract: Over 100 years ago, Santiago Ramòn y Cajal proposed that the nervous substrate for learning and memory is a strengthening of the connections, or even a building of new connections, between nerve cells. We now have definitive evidence that this occurs. The formation of new dendritic spines has been seen after long-term potentiation, and it should tell us much about long-term storage of information in the brain.

Date: 1999
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DOI: 10.1038/19857

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