Many vessels, faulty gene

William G. Kaelin ()
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William G. Kaelin: Dana-Farber Cancer Institute

Nature, 1999, vol. 399, issue 6733, 203-204

Abstract: The von Hippel-Lindau (VHL) cancer syndrome is caused by mutations in theVHLgene, and is characterized by development of blood-vessel tumours. Production of blood vessels is normally stimulated when cells are short of oxygen. But when oxygen is plentiful, the factors that stimulate production of vessels are destroyed. It now turns out that the VHL protein is responsible for this destruction. So, when it is mutated, the result is too many vessels and tumour formation.

Date: 1999
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DOI: 10.1038/20309

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