Dead end for neurodegeneration?

Christian Haass ()
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Christian Haass: Adolf Butenandt Institute, Ludwig-Maximilians-University

Nature, 1999, vol. 399, issue 6733, 204-207

Abstract: Caspases — the protein-digesting enzymes central to regulated cell death — are implicated in neurodegenerative diseases such as Huntington's and Alzheimer's. This is now illustrated by two studies. In the first, symptoms of Huntington's disease are less severe when caspase-1-mediated cleavage of the huntingtin protein is blocked. And in the second, the cytoplasmic domain of the beta-amyloid precursor protein is shown to be cleaved directly by caspase-3, leading to increased production of the amyloid-beta peptide.

Date: 1999
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DOI: 10.1038/20314

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