Snail mail to the nucleus

Iain W. Mattaj () and Elena Conti ()
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Iain W. Mattaj: the European Molecular Biology Laboratory
Elena Conti: the European Molecular Biology Laboratory

Nature, 1999, vol. 399, issue 6733, 208-210

Abstract: Large molecules are constantly shuffled between the nucleus and cytoplasm via channels called nuclear-pore complexes. Transport is mediated by receptor proteins called importins and exportins, which bind the cargo and shuttle it through the pore. The crystal structures of two importins — one with its cargo and one with the GTP-bound form of the small GTPase Ran — are now reported. There are telling similarities and differences between these two structures.

Date: 1999
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DOI: 10.1038/20322

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