Closing the joint

John M. Coffin () and Naomi Rosenberg
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John M. Coffin: Tufts University
Naomi Rosenberg: Tufts University

Nature, 1999, vol. 399, issue 6735, 413-415

Abstract: To insert their genetic material into a host's DNA, retroviruses use an enzyme called integrase. But integrase leaves a gap around the inserted sequence around the host's DNA -- a gap that must be repaired before DNA synthesis can proceed. New work indicates that, unexpectedly, one of the host's damage-sensing systems involving the DNA-dependent protein kinase may be required.

Date: 1999
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DOI: 10.1038/20810

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