Tunnel vision

Dagmar Ringe () and Gregory A. Petsko ()
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Dagmar Ringe: Dagmar Ringe and Gregory A. Petsko are at the Rosenstiel Basic Medical Sciences Research Center, Brandeis University
Gregory A. Petsko: Dagmar Ringe and Gregory A. Petsko are at the Rosenstiel Basic Medical Sciences Research Center, Brandeis University

Nature, 1999, vol. 399, issue 6735, 417-418

Abstract: On the face of it, it seems surprising that thermophilic enzymes should lose or have reduced catalytic activity at the lower temperatures at which other enzymes function perfectly well. At least in one example, an explanation seems to lie in the reduced quantum-mechanical tunnelling behaviour that results from the thermophilic enzyme's lesser flexibility at these lower temperatures.

Date: 1999
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DOI: 10.1038/20819

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