A vancomycin surprise

Michael S. Gilmore and James A. Hoch ()
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Michael S. Gilmore: University of Oklahoma Health Sciences Center
James A. Hoch: University of Oklahoma Health Sciences Center

Nature, 1999, vol. 399, issue 6736, 525-527

Abstract: Bacteria are becoming increasingly clever, and can now outwit most of the antibiotics that we throw at them. The results of a new study show not only that some clinical isolates of penicillin-resistantS. pneumoniaeare also tolerant to vancomycin, but they also give us a clue to how the bacteria do this. The key is a two-component signal-transduction system.

Date: 1999
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DOI: 10.1038/21070

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