Hiding messages in DNA microdots

Catherine Taylor Clelland (), Viviana Risca and Carter Bancroft ()
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Catherine Taylor Clelland: Mount Sinai School of Medicine
Viviana Risca: Paul D. Schreiber High School
Carter Bancroft: Mount Sinai School of Medicine

Nature, 1999, vol. 399, issue 6736, 533-534

Abstract: Abstract The microdot is a means of concealing messages (steganography)1 that was developed by Professor Zapp and used by German spies in the Second World War to transmit secret information2. A microdot (“the enemy's masterpiece of espionage”2) was a greatly reduced photograph of a typewritten page that was pasted over a full stop in an innocuous letter2. We have taken the microdot a step further and developed a DNA-based, doubly steganographic technique for sending secret messages. A DNA-encoded message is first camouflaged within the enormous complexity of human genomic DNA and then further concealed by confining this sample to a microdot.

Date: 1999
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DOI: 10.1038/21092

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