Assignment of circadian function for the Neurospora clock gene frequency

Martha Merrow (), Michael Brunner and Till Roenneberg ()
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Martha Merrow: Institutes for Medical Psychology and
Michael Brunner: Physiological Chemistry, Ludwig Maximilians University
Till Roenneberg: Institutes for Medical Psychology and

Nature, 1999, vol. 399, issue 6736, 584-586

Abstract: Abstract Circadian clocks consist of three elements: entrainment pathways (inputs), the mechanism generating the rhythmicity (oscillator), and the output pathways that control the circadian rhythms. It is difficult to assign molecular clock components to any one of these elements. Experiments show that inputs can be circadianly regulated1,2,3 and outputs can feed back on the oscillator4,5. Mathematical simulations indicate that under- or overexpression of a gene product can result in arrhythmicity, whether the protein is part of the oscillator or substantially part of a rhythmically expressed input pathway6. To distinguish between these two possibilities, we used traditional circadian entrainment protocols7,8 on a genetic model system, Neurospora crassa.

Date: 1999
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DOI: 10.1038/21190

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