Variants on a theme
Richard D. Wood
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Richard D. Wood: Imperial Cancer Research Fund, Clare Hall Laboratories
Nature, 1999, vol. 399, issue 6737, 639-640
Abstract:
Our DNA is constantly under attack, and most cells try to repair any damage before they replicate their DNA. But some cells simply bypass the damaged sites. Such bypass — known as translesion synthesis — does not work properly in a rare, inherited, cancer-prone syndrome called xeroderma pigmentosum ‘variant’. The defective protein involved has now been identified as DNA polymeraseη, the seventh mammalian DNA polymerase to be identified.
Date: 1999
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DOI: 10.1038/21323
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