Decoding the Reelin signal

Isabelle Bar and André M. Goffinet ()
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Isabelle Bar: Neurobiology Unit, University of Namur Medical School
André M. Goffinet: Neurobiology Unit, University of Namur Medical School

Nature, 1999, vol. 399, issue 6737, 645-646

Abstract: Thereelermutant mouse has been used as a model of abnormal brain development for over 50 years. These mice lack a protein called Reelin, and they show a series of developmental abnormalities. Mice lacking two other proteins — the very low density lipoprotein receptor, and the apolipoprotein E receptor-2 — have now been found to show the same abnormalities, indicating that these molecules are involved in the Reelin signalling pathway.

Date: 1999
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DOI: 10.1038/21340

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