DNA damage enables p73

Eileen White () and Carol Prives ()
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Eileen White: Howard Hughes Medical Institute, Center for Advanced Biotechnology and Medicine, Cancer Institute of New Jersey, and Rutgers University
Carol Prives: Columbia University, Sherman Fairchild Center for the Life Sciences

Nature, 1999, vol. 399, issue 6738, 735-737

Abstract: The'guardian of the genome', p53, is the best-known tumour-suppressor gene. Two other proteins — p63 and p73 — have similar sequences and properties to p53. But p53 is the only one to be induced by DNA damage. Or at least it was. A new study shows that, in fact, p73 is also induced by DNA damage via the non-receptor tyrosine kinase c-Abl.

Date: 1999
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DOI: 10.1038/21539

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