Pinning down phosphorylated tau

Michel Goedert ()
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Michel Goedert: MRC Laboratory of Molecular Biology

Nature, 1999, vol. 399, issue 6738, 739-740

Abstract: A defining characteristic of certain neurodegenerative diseases is the formation of filamentous deposits of a microtubule-associated protein called tau, in an abnormal hyperphosphorylated form. New work shows that this form of tau can bind to a prolyl isomerase called Pin1, and that this interaction restores the biological activity of phosphorylated tau. This discovery could open the way to developing therapeutic compounds that reduce the pool of functionally impaired tau.

Date: 1999
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DOI: 10.1038/21550

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