Limbs move beyond the Radical fringe

Nian Zhang and Thomas Gridley ()
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Nian Zhang: The Jackson Laboratory
Thomas Gridley: The Jackson Laboratory

Nature, 1999, vol. 399, issue 6738, 743-743

Abstract: Abstract Zhang and Gridley reply — We too have created mice that have a large deletion in the Radical fringe gene and investigated the resulting effect on their development. Our results agree with those of Moran et al. in showing that Rfng is not an essential gene in mice, but they do not support the idea that the presence of a neo- selection cassette inserted into the Rfng locus invariably leads to embryonic lethality.

Date: 1999
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DOI: 10.1038/21563

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