TRA-1 regulates the cellular distribution of the tra-2 mRNA in C. elegans

L. E. Graves, S. Segal and E. B. Goodwin ()
Additional contact information
L. E. Graves: Northwestern University Medical School
S. Segal: Northwestern University Medical School
E. B. Goodwin: Northwestern University Medical School

Nature, 1999, vol. 399, issue 6738, 802-805

Abstract: Abstract The GLI protein family is involved in several key developmental processes in both vertebrates and invertebrates. The Drosophila GLI protein, Cubitus interuptus (Ci), regulates segment polarity and wing and leg development. In vertebrates, the GLI proteins control neural, lung, bone and gut development1. In the nematode Caenorhabditis elegans, the GLI family member TRA-1 is necessary for normal sexual development2,3. GLI, Ci and TRA-1 each contain five zinc-finger domains and bind the identical DNA sequence. Previous analyses are consistent with these proteins being transcription factors4,5. Here we show that TRA-1 can act post-transcriptionally to govern gene activity. Our results indicate that the binding of TRA-1 to the 3′ untranslated region oftra-2 regulates the export of tra-2 messenger RNA from thenucleus. The fact that TRA-1 is part of a conserved family ofproteins raises the possibility that GLI family members are both transcriptional and post-transcriptional regulators of gene expression.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/21682 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:399:y:1999:i:6738:d:10.1038_21682

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/21682

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().