The changing landscape of ischaemic brain injury mechanisms

Jin-Moo Lee, Gregory J. Zipfel and Dennis W. Choi
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Jin-Moo Lee: Washington University School of Medicine
Gregory J. Zipfel: Washington University School of Medicine
Dennis W. Choi: Washington University School of Medicine

Nature, 1999, vol. 399, issue 6738, A7-A14

Abstract: Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

Date: 1999
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DOI: 10.1038/399a007

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