Mox2 is a component of the genetic hierarchy controlling limb muscle development

Baljinder S. Mankoo, Nina S. Collins, Peter Ashby, Elena Grigorieva, Larysa H. Pevny, Albert Candia, Christopher V. E. Wright, Peter W. J. Rigby and Vassilis Pachnis ()
Additional contact information
Baljinder S. Mankoo: Divisions of Developmental Neurobiology
Nina S. Collins: Divisions of Developmental Neurobiology
Peter Ashby: Divisions of Eukaryotic Molecular Genetics
Elena Grigorieva: Divisions of Developmental Neurobiology
Larysa H. Pevny: MRC National Institute for Medical Research
Albert Candia: Divisions of Vanderbilt Medical School
Christopher V. E. Wright: Divisions of Vanderbilt Medical School
Peter W. J. Rigby: Divisions of Eukaryotic Molecular Genetics
Vassilis Pachnis: Divisions of Developmental Neurobiology

Nature, 1999, vol. 400, issue 6739, 69-73

Abstract: Abstract The skeletal muscles of the limbs develop from myogenic progenitors that originate in the paraxial mesoderm and migrate intothe limb-bud mesenchyme1. Among the genes known to be important for muscle development in mammalian embryos are those encoding the basic helix-loop-helix (bHLH) myogenic regulatory factors (MRFs; MyoD, Myf5, myogenin and MRF4)2,3,4 and Pax3, a paired-type homeobox gene that is critical for the development of limb musculature5,6,7. Mox1 and Mox2 are closely related homeobox genes that are expressed in overlapping patterns in the paraxial mesoderm and its derivatives8,9. Here we show that mice homozygous for a null mutation of Mox2 have a developmental defect of the limb musculature, characterized by an overall reduction in muscle mass and elimination of specific muscles. Mox2 is not needed for the migration of myogenic precursors into the limb bud, but it is essential for normal appendicular muscle formation and for the normal regulation of myogenic genes, as demonstrated by the downregulation of Pax3 and Myf5 but not MyoD in Mox2-deficient limb buds. Our findings show that the MOX2 homeoprotein is an important regulator of vertebrate limb myogenesis.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/21892 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:400:y:1999:i:6739:d:10.1038_21892

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/21892

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().