Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells

Britta C. Urban, David J. P. Ferguson, Arnab Pain, Nick Willcox, Magdalena Plebanski, Jonathan M. Austyn and David J. Roberts ()
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Britta C. Urban: Institute of Molecular Medicine
David J. P. Ferguson: Nuffield Department of Pathology
Arnab Pain: Institute of Molecular Medicine
Nick Willcox: Institute of Molecular Medicine
Magdalena Plebanski: Molecular Immunology Group
Jonathan M. Austyn: Nuffield Department of Surgery
David J. Roberts: Institute of Molecular Medicine

Nature, 1999, vol. 400, issue 6739, 73-77

Abstract: Abstract The malaria parasite Plasmodium falciparum is one of the most successful human pathogens. Specific virulence factors remain poorly defined, although the adhesion of infected erythrocytes tothe venular endothelium has been associated with some of thesyndromes of severe disease1. Immune responses cannot prevent the development of symptomatic infections throughout life, and clinical immunity to the disease develops only slowly during childhood. An understanding of the obstacles to the development of protective immunity is crucial for developing rational approaches to prevent the disease. Here we show that intact malaria-infected erythrocytes adhere to dendritic cells, inhibit the maturation of dendritic cells and subsequently reduce their capacity to stimulate T cells. These data demonstrate both a novel mechanism by which malaria parasites induce immune dysregulation and a functional role beyond endothelial adhesion for the adhesive phenotypes expressed at the surface of infected erythrocytes.

Date: 1999
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DOI: 10.1038/21900

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