Breaking the chain of addiction

Gary Aston-Jones () and Jonathan Druhan
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Gary Aston-Jones: University of Pennsylvania School of Medicine, VAMC (151), University and Woodland Avenues
Jonathan Druhan: University of Pennsylvania School of Medicine, VAMC (151), University and Woodland Avenues

Nature, 1999, vol. 400, issue 6742, 317-319

Abstract: Cocaine addicts often find themselves in a cycle of withdrawal and relapse, but a newly developed drug might break this cycle. The drug - known as BP 897 - is a partial agonist for the dopamine D3receptor subtype. In the absence of the neurotransmitter dopamine, BP 897 stimulates the D3receptor. But when cocaine has been taken and levels of dopamine are increased, BP 897 antagonizes the D3receptor.

Date: 1999
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DOI: 10.1038/22432

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