Directional guidance of neuronal migration in the olfactory system by the protein Slit

Wei Wu, Kit Wong, Jin-hui Chen, Zhi-hong Jiang, Sophie Dupuis, Jane Y. Wu () and Yi Rao ()
Additional contact information
Wei Wu: Laboratory of Molecular Neurobiology, Shanghai Research Center for the Life Sciences and The National Institute of Neuroscience, The Chinese Academy of Sciences
Kit Wong: Washington University School of Medicine
Jin-hui Chen: Laboratory of Molecular Neurobiology, Shanghai Research Center for the Life Sciences and The National Institute of Neuroscience, The Chinese Academy of Sciences
Zhi-hong Jiang: Washington University School of Medicine
Sophie Dupuis: Washington University School of Medicine
Jane Y. Wu: Washington University School of Medicine
Yi Rao: Washington University School of Medicine

Nature, 1999, vol. 400, issue 6742, 331-336

Abstract: Abstract Although cell migration is crucial for neural development, molecular mechanisms guiding neuronal migration have remained unclear. Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb. Our results provide a direct demonstration of a molecular cue whose concentration gradient guides the direction of migrating neurons. They also support a common guidance mechanism for axon projection and neuronal migration and suggest that Slit may provide a molecular tool with potential therapeutic applications in controlling and directing cell migration.

Date: 1999
References: Add references at CitEc
Citations: View citations in EconPapers (2)

Downloads: (external link)
https://www.nature.com/articles/22477 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:400:y:1999:i:6742:d:10.1038_22477

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/22477

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().