Developmental model for thalidomide action

Reinhard Neubert, Hans-Joachim Merker () and Diether Neubert
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Reinhard Neubert: Institute of Clinical Pharmacology
Hans-Joachim Merker: Toxicology, and Institute of Anatomy, Benjamin Franklin Medical Centre, Freie Universität
Diether Neubert: Institute of Clinical Pharmacology

Nature, 1999, vol. 400, issue 6743, 419-420

Abstract: Abstract Tabin has proposed a progress-zone model1, based on published data, to explain the inhibition of limb morphogenesis by thalidomide. We do not think that his model convincingly explains the main features of thalidomide action.

Date: 1999
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DOI: 10.1038/22685

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