The complete nucleotide sequence of chromosome 3 of Plasmodium falciparum

S. Bowman (), D. Lawson, D. Basham, D Brown, T. Chillingworth, C. M. Churcher, A. Craig, R. M. Davies, K. Devlin, T. Feltwell, S. Gentles, R. Gwilliam, N. Hamlin, D. Harris, S. Holroyd, T. Hornsby, P. Horrocks, K. Jagels, B. Jassal, S. Kyes, J. McLean, S. Moule, K. Mungall, L. Murphy, K. Oliver, M. A. Quail, M.-A. Rajandream, S. Rutter, J. Skelton, R. Squares, S. Squares, J. E. Sulston, S. Whitehead, J. R. Woodward, C. Newbold and B. G. Barrell
Additional contact information
S. Bowman: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
D. Lawson: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
D. Basham: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
D Brown: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
T. Chillingworth: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
C. M. Churcher: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
A. Craig: Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
R. M. Davies: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
K. Devlin: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
T. Feltwell: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
S. Gentles: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
R. Gwilliam: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
N. Hamlin: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
D. Harris: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
S. Holroyd: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
T. Hornsby: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
P. Horrocks: Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
K. Jagels: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
B. Jassal: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
S. Kyes: Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
J. McLean: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
S. Moule: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
K. Mungall: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
L. Murphy: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
K. Oliver: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
M. A. Quail: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
M.-A. Rajandream: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
S. Rutter: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
J. Skelton: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
R. Squares: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
S. Squares: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
J. E. Sulston: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
S. Whitehead: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
J. R. Woodward: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus
C. Newbold: Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital
B. G. Barrell: Pathogen Sequencing Unit, Sanger Centre, Wellcome Trust Genome Campus

Nature, 1999, vol. 400, issue 6744, 532-538

Abstract: Abstract Analysis of Plasmodium falciparum chromosome 3, and comparison with chromosome 2, highlights novel features of chromosome organization and gene structure. The sub-telomeric regions of chromosome 3 show a conserved order of features, including repetitive DNA sequences, members of multigene families involved in pathogenesis and antigenic variation, a number of conserved pseudogenes, and several genes of unknown function. A putative centromere has been identified that has a core region of about 2 kilobases with an extremely high (adenine + thymidine) composition and arrays of tandem repeats. We have predicted 215 protein-coding genes and two transfer RNA genes in the 1,060,106-base-pair chromosome sequence. The predicted protein-coding genes can be divided into three main classes: 52.6% are not spliced, 45.1% have a large exon with short additional 5′ or 3′ exons, and 2.3% have a multiple exon structure more typical of higher eukaryotes.

Date: 1999
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DOI: 10.1038/22964

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