Developing B-cell theories

David G. Schatz ()
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David G. Schatz: Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine

Nature, 1999, vol. 400, issue 6745, 615-617

Abstract: The clonal-selection theory of B- and T-cell development holds that B and T cells have a diverse array of antigen receptors before they ever encounter antigen. Increasingly, though, the idea is taking hold that antigen-specific interactions may, in fact, produce new receptors. Two studies now describe a powerful tool to allow further study of these issues, and the results may help to reconcile previous findings with the clonal-selection theory.

Date: 1999
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DOI: 10.1038/23134

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