Chemokine control of HIV-1 infection

Mario Mellado, José Miguel Rodríguez-Frade, Antonio J. Vila-Coro, Ana Martín de Ana and Carlos Martínez-A. ()
Additional contact information
Mario Mellado: Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid
José Miguel Rodríguez-Frade: Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid
Antonio J. Vila-Coro: Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid
Ana Martín de Ana: Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid
Carlos Martínez-A.: Centro Nacional de Biotecnología/CSIC, Universidad Autónoma de Madrid

Nature, 1999, vol. 400, issue 6746, 723-724

Abstract: Abstract Chemokines are proinflammatory cytokines that attract and activate specific types of leukocyte1. There are two main chemokine families, based on the position of the first two cysteine residues: the CC and the CXC chemokines1. Chemokines mediate their effects through interactions with seven-transmembrane-spanning glyco-protein receptors coupled to a G-protein signalling pathway1. Chemokine receptors normally undergo a ligand-mediated homodimerization process, which is required for Ca2+ flux and chemotaxis2. Here we show that in the chemokine response it is possible for heterodimerization, rather than homodimerization, to occur between a mutant form of the CCR2 receptor (the CCR2V64I receptor), which helps to delay the development of AIDS in HIV-1-infected individuals, and the CCR5 or CXCR4 chemokine receptor, which are used by HIV to gain entry into cells. These results may explain why AIDS takes longer to develop in HIV-1-infected individuals carrying the CCR2V64I mutation3.

Date: 1999
References: Add references at CitEc
Citations:

Downloads: (external link)
https://www.nature.com/articles/23382 Abstract (text/html)
Access to the full text of the articles in this series is restricted.

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:nat:nature:v:400:y:1999:i:6746:d:10.1038_23382

Ordering information: This journal article can be ordered from
https://www.nature.com/

DOI: 10.1038/23382

Access Statistics for this article

Nature is currently edited by Magdalena Skipper

More articles in Nature from Nature
Bibliographic data for series maintained by Sonal Shukla () and Springer Nature Abstracting and Indexing ().