Trapped in the act

Tania A. Baker ()
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Tania A. Baker: Massachusetts Institute of Technology, and the Howard Hughes Medical Institute

Nature, 1999, vol. 401, issue 6748, 29-30

Abstract: When a protein has been selected for destruction it is usually tagged with a specific destruction signal then it is thought to be unfolded and fed into the protein-digesting machinery. Such global unfolding is now demonstrated directly for the first time, in the ClpAP bacterial protein-destruction system, through the clever use of a green fluorescent protein as the target.

Date: 1999
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DOI: 10.1038/43341

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