Lipid membranes shape up

Suzie J. Scales () and Richard H. Scheller
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Suzie J. Scales: Howard Hughes Medical Institute, Stanford University School of Medicine
Richard H. Scheller: Howard Hughes Medical Institute, Stanford University School of Medicine

Nature, 1999, vol. 401, issue 6749, 123-124

Abstract: When synaptic vesicles are recycled, they are 'pinched' off from the presynaptic membrane. A protein called dynamin was thought to be the 'pinchase', but it now turns out that dynamin's function is to recruit another protein, endophilin I, to the neck of the vesicle. Endophilin I affects the composition of the lipids in the vesicle's membrane, influencing its curvature and facilitating the pinching process.

Date: 1999
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DOI: 10.1038/43582

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