The novel Cer-like protein Caronte mediates the establishment of embryonic left–right asymmetry

Concepción Rodríguez Esteban, Javier Capdevila, Aris N. Economides, Jaime Pascual, Ángel Ortiz and Juan Carlos Izpisúa Belmonte ()
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Concepción Rodríguez Esteban: The Salk Institute for Biological Studies, Gene Expression Laboratory
Javier Capdevila: The Salk Institute for Biological Studies, Gene Expression Laboratory
Aris N. Economides: Regeneron Pharmaceuticals, Inc.
Jaime Pascual: The Scripps Research Institute
Ángel Ortiz: The Scripps Research Institute
Juan Carlos Izpisúa Belmonte: The Salk Institute for Biological Studies, Gene Expression Laboratory

Nature, 1999, vol. 401, issue 6750, 243-251

Abstract: Abstract In the chick embryo, left–right asymmetric patterns of gene expression in the lateral plate mesoderm are initiated by signals located in and around Hensen's node. Here we show that Caronte (Car), a secreted protein encoded by a member of the Cerberus/Dan gene family, mediates the Sonic hedgehog (Shh)-dependent induction of left-specific genes in the lateral plate mesoderm. Car is induced by Shh and repressed by fibroblast growth factor-8 (FGF-8). Car activates the expression of Nodal by antagonizing a repressive activity of bone morphogenic proteins (BMPs). Our results define a complex network of antagonistic molecular interactions between Activin, FGF-8, Lefty-1, Nodal, BMPs and Car that cooperate to control left–right asymmetry in the chick embryo.

Date: 1999
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DOI: 10.1038/45738

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