Engineering a broken heart

Peter J. Scambler ()
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Peter J. Scambler: Molecular Medicine Unit, Institute of Child Health

Nature, 1999, vol. 401, issue 6751, 335-337

Abstract: Many birth defects are caused by chromosomal insertions or deletions. The most common deletion syndrome in humans is DiGeorge syndrome, one of the symptoms of which is congenital heart disease. DiGeorge syndrome was thought to be caused by deletion of just one gene, but the results of a targeted-deletion study indicate that more than one gene is likely to be affected.

Date: 1999
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DOI: 10.1038/43804

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