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Mating, channels and kidney cysts

Scott W. Emmons () and Stefan Somlo ()
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Scott W. Emmons: Albert Einstein College of Medicine
Stefan Somlo: Section of Nephrology, Yale University School of Medicine

Nature, 1999, vol. 401, issue 6751, 339-340

Abstract: People with mutations in either of two proteins known as polycystin-1 and polycystin-2 develop polycystic kidney disease. Studies on the nematode worm and the frogXenopus laevisare now helping researchers to work out the normal functions of these proteins. It seems that polycystin-1-related proteins act as receptors, which regulate the activity of channels containing polycystin-2-related proteins.

Date: 1999
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DOI: 10.1038/43810

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