Casein kinase I transduces Wnt signals

John M. Peters, Renée M. McKay, James P. McKay and Jonathan M. Graff ()
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John M. Peters: Center for Developmental Biology, UT Southwestern Medical Center
Renée M. McKay: Center for Developmental Biology, UT Southwestern Medical Center
Jonathan M. Graff: Center for Developmental Biology, UT Southwestern Medical Center

Nature, 1999, vol. 401, issue 6751, 345-350

Abstract: Abstract The Wnt signalling cascade is essential for the development of both invertebrates and vertebrates, and is altered during tumorigenesis. Although a general framework for Wnt signalling has been elucidated, not all of the components have been identified. Here we describe a serine kinase, casein kinase I (CKI), which was isolated by expression cloning in Xenopus embryos. CKI reproduces several properties of Wnt signals, including generation of complete dorsal axes, stabilization of β-catenin and induction of genes that are direct targets of Wnt signals. Dominant-negative forms of CKI and a pharmacological blocker of CKI inhibited Wnt signals in Xenopus. Inhibiting CKI in Caenorhabditis elegans generated worms with a mom phenotype, indicative of a loss of Wnt signals. In addition, CKI bound to and increased the phosphorylation of dishevelled, a known component of the Wnt pathway. These data indicate that CKI may be a conserved component of the Wnt pathway.

Date: 1999
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DOI: 10.1038/43830

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