Cutting red-cell production

Stuart H. Orkin () and Mitchell J. Weiss
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Stuart H. Orkin: Ontogeny Inc.
Mitchell J. Weiss: Ontogeny Inc.

Nature, 1999, vol. 401, issue 6752, 433-435

Abstract: The production of red blood cells is a finely balanced process: too many and blood circulation is impaired; too few and the tissues don't get enough oxygen. Control of this process has now been pinned down to the opposite effects of two signalling pathways -- one involving cell-death receptors, and the other involving the peptide hormone erythropoietin -- on a transcription factor called GATA-1.

Date: 1999
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DOI: 10.1038/46699

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