Fools rush in

Helen Piwnica-Worms ()
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Helen Piwnica-Worms: Howard Hughes Medical Institute, Washington University School of Medicine

Nature, 1999, vol. 401, issue 6753, 535-536

Abstract: When a dividing cell's DNA is damaged, that cell needs to stop dividing so that the damage can be repaired. There are two main points at which the cell-division cycle can be halted. A study of one of these -- the G2 DNA-damage checkpoint -- shows that there are two parts to checkpoint control. The first, checkpoint initiation, does not seem to depend on the tumour-suppressor protein p53. But maintenance of this checkpoint, it seems, does.

Date: 1999
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DOI: 10.1038/44029

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