Wavering on commitment

Suzanne Cory ()
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Suzanne Cory: The Walter and Eliza Hall Institute of Medical Research

Nature, 1999, vol. 401, issue 6753, 538-539

Abstract: The patriarch of the haematopoietic system, which generates all the various kinds of specialized blood cells, is a stem cell found in adult bone marrow. Studies of how it differentiates have revealed a remarkable finding -- if this cell is denied the transcription factor Pax5 at a particular stage, instead of becoming an antibody-producing B cell some six other options become available to it.

Date: 1999
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DOI: 10.1038/44035

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