Controlling the cellular brakes

Peter Carmeliet ()
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Peter Carmeliet: the Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, Campus Gasthuisberg

Nature, 1999, vol. 401, issue 6754, 657-658

Abstract: How does a cell decide to become a nerve cell and not, say, an endothelial cell? Such cell-fate decisions are made by certain 'master' genes, which switch on cellular programmes to differentiate precursor cells into various cell types. Differentiation is thought to be kept in check by molecular 'brakes', and a study of mice lacking Id1 and Id3 indicates that these proteins could act as just such brakes.

Date: 1999
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DOI: 10.1038/44304

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