Searching for FLASH domains

Takaharu Kimura, Yuzuru Imai and Shin Yonehara ()
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Takaharu Kimura: Institute for Virus Research, Kyoto University
Yuzuru Imai: Institute for Virus Research, Kyoto University
Shin Yonehara: Institute for Virus Research, Kyoto University

Nature, 1999, vol. 401, issue 6754, 662-663

Abstract: Abstract We do not consider that our inferences about FLASH function are misleading because they were deduced from functional analyses1. We originally identified the death-effector domain (DED)-binding activity of the DED-recruiting domain (DRD) of FLASH before analysing the structural homology between the DED and DRD domains. Moreover, we deduced the self-association activity of FLASH through its central region from functional analysis of several deletion mutants of mouse FLASH. We note that self-association activity of CED-4-homologous proteins is required for the activation of caspases2.

Date: 1999
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DOI: 10.1038/44320

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