Toll gates for pathogen selection

Richard J. Ulevitch ()
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Richard J. Ulevitch: The Scripps Research Institute

Nature, 1999, vol. 401, issue 6755, 755-756

Abstract: Mammals and flies both stave off pathogens using the innate immune response. In the fruit fly this involves cell-surface receptors belonging to the Toll family, which mediate separate anti-bacterial and anti-fungal responses in the same type of cell. Studies of two mammalian Toll-like receptors, TLR2 and TLR4, indicate that this system is also used in the innate immune responses of higher animals.

Date: 1999
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DOI: 10.1038/44490

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