Grabbing phosphoproteins

Michael B. Yaffe () and Lewis C. Cantley ()
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Michael B. Yaffe: Harvard Medical School/Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine
Lewis C. Cantley: Harvard Medical School/Beth Israel Deaconess Medical Center, Harvard Institutes of Medicine

Nature, 1999, vol. 402, issue 6757, 30-31

Abstract: The control of complex cellular events relies on precise regulation of signalling molecules. The activity of many such proteins is controlled by adding a phosphate group to certain amino acids such as tyrosine, serine and threonine. A well-known motif -- the SH2 domain -- binds to phosphotyrosine residues. And a new family of proteins that bind phosphoserine and phosphothreonine is now emerging.

Date: 1999
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DOI: 10.1038/46925

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