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Mutant mice live longer

Leonard Guarente ()
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Leonard Guarente: Massachusetts Institute of Technology

Nature, 1999, vol. 402, issue 6759, 243-245

Abstract: All known methods to increase lifespan come at a price. Usually, the costs are problems in development and fertility. But mutant mice have now been generated that live almost one-third longer than normal yet with no apparent side effects. These mice contain mutations in the gene that encodes a protein called p66shc, which is thought to be involved in the response to oxidative DNA damage.

Date: 1999
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DOI: 10.1038/46185

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