Kainate receptors are involved in synaptic plasticity

Zuner A. Bortolotto, Vernon R. J. Clarke, Caroline M. Delany, Michael C. Parry, Ilse Smolders, Michel Vignes, Ken H. Ho, Peter Miu, Bradford T. Brinton, Robert Fantaske, Ann Ogden, Mary Gates, Paul L. Ornstein, David Lodge, David Bleakman and Graham L. Collingridge
Additional contact information
Zuner A. Bortolotto: MRC Centre for Synaptic Plasticity, Medical School, University of Bristol
Vernon R. J. Clarke: MRC Centre for Synaptic Plasticity, Medical School, University of Bristol
Caroline M. Delany: MRC Centre for Synaptic Plasticity, Medical School, University of Bristol
Michael C. Parry: MRC Centre for Synaptic Plasticity, Medical School, University of Bristol
Ilse Smolders: MRC Centre for Synaptic Plasticity, Medical School, University of Bristol
Michel Vignes: MRC Centre for Synaptic Plasticity, Medical School, University of Bristol
Ken H. Ho: Allelix Biopharmaceuticals
Peter Miu: Allelix Biopharmaceuticals
Bradford T. Brinton: Allelix Biopharmaceuticals
Robert Fantaske: Allelix Biopharmaceuticals
Ann Ogden: Eli Lilly & Co., Lilly Corporate Centre
Mary Gates: Eli Lilly & Co., Lilly Corporate Centre
Paul L. Ornstein: Eli Lilly & Co., Lilly Corporate Centre
David Lodge: Eli Lilly & Co., Lilly Corporate Centre
David Bleakman: Eli Lilly & Co., Lilly Corporate Centre
Graham L. Collingridge: MRC Centre for Synaptic Plasticity, Medical School, University of Bristol

Nature, 1999, vol. 402, issue 6759, 297-301

Abstract: Abstract The ability of synapses to modify their synaptic strength in response to activity is a fundamental property of the nervous system and may be an essential component of learning and memory1. There are three classes of ionotropic glutamate receptor, namely NMDA (N-methyl-D-aspartate), AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-4-propionic acid) and kainate receptors2; critical roles in synaptic plasticity have been identified for two of these. Thus, at many synapses in the brain, transient activation of NMDA receptors leads to a persistent modification in the strength of synaptic transmission mediated by AMPA receptors3,4. Here, to determine whether kainate receptors5,6,7 are involved in synaptic plasticity, we have used a new antagonist, LY382884 ((3S, 4aR, 6S, 8aR)-6-((4-carboxyphenyl)methyl-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid), which antagonizes kainate receptors at concentrations that do not affect AMPA or NMDA receptors. We find that LY382884 is a selective antagonist at neuronal kainate receptors containing the GluR5 subunit. It has no effect on long-term potentiation (LTP) that is dependent on NMDA receptors but prevents the induction of mossy fibre LTP, which is independent of NMDA receptors. Thus, kainate receptors can act as the induction trigger for long-term changes in synaptic transmission.

Date: 1999
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DOI: 10.1038/46290

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