The dynamics of chromosome evolution in birds and mammals

David W. Burt (), Charlotte Bruley, Ian C. Dunn, Cheryl T. Jones, Anne Ramage, Andy S. Law, David R. Morrice, Ian R. Paton, Jacqueline Smith, Dawn Windsor, Alexei Sazanov, Ruedi Fries and David Waddington
Additional contact information
David W. Burt: Roslin Institute (Edinburgh)
Charlotte Bruley: Roslin Institute (Edinburgh)
Ian C. Dunn: Roslin Institute (Edinburgh)
Cheryl T. Jones: Roslin Institute (Edinburgh)
Anne Ramage: Roslin Institute (Edinburgh)
Andy S. Law: Roslin Institute (Edinburgh)
David R. Morrice: Roslin Institute (Edinburgh)
Ian R. Paton: Roslin Institute (Edinburgh)
Jacqueline Smith: Roslin Institute (Edinburgh)
Dawn Windsor: Roslin Institute (Edinburgh)
Alexei Sazanov: Lehrstuhl fur Tierzucht, TUM, Freising
Ruedi Fries: Lehrstuhl fur Tierzucht, TUM, Freising
David Waddington: Roslin Institute (Edinburgh)

Nature, 1999, vol. 402, issue 6760, 411-413

Abstract: Abstract Comparative mapping, which compares the location of homologous genes in different species, is a powerful tool for studying genome evolution1. Comparative maps suggest that rates of chromosomal change in mammals can vary from one to ten rearrangements per million years1,2,3,4. On the basis of these rates we would expect 84 to 600 conserved segments in a chicken comparison with human or mouse. Here we build comparative maps between these species and estimate that numbers of conserved segments are in the lower part of this range. We conclude that the organization of the human genome is closer to that of the chicken than the mouse and by adding comparative mapping results from a range of vertebrates, we identify three possible phases of chromosome evolution. The relative stability of genomes such as those of the chicken and human will enable the reconstruction of maps of ancestral vertebrates.

Date: 1999
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DOI: 10.1038/46555

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