Synexpression groups in eukaryotes

Christof Niehrs and Nicolas Pollet
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Christof Niehrs: Deutsches Krebsforschungszentrum
Nicolas Pollet: Deutsches Krebsforschungszentrum

Nature, 1999, vol. 402, issue 6761, 483-487

Abstract: Abstract In 1960, Jacob and Monod described the bacterial operon, a cluster of functionally interacting genes whose expression is tightly coordinated. Global expression analysis has shown that the highly coordinate expression of genes functioning in common processes is also a widespread phenomenon in eukaryotes. These sets of co-regulated genes, or ‘synexpression groups’, show a striking parallel to the operon, and may be a key determinant facilitating evolutionary change leading to animal diversity.

Date: 1999
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DOI: 10.1038/990025

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