The temporal requirement for endothelin receptor-B signalling during neural crest development

Myung K. Shin, John M. Levorse, Robert S. Ingram and Shirley M. Tilghman
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Myung K. Shin: Howard Hughes Medical Institute and Department of Molecular Biology Princeton University
John M. Levorse: Howard Hughes Medical Institute and Department of Molecular Biology Princeton University
Robert S. Ingram: Howard Hughes Medical Institute and Department of Molecular Biology Princeton University
Shirley M. Tilghman: Howard Hughes Medical Institute and Department of Molecular Biology Princeton University

Nature, 1999, vol. 402, issue 6761, 496-501

Abstract: Abstract Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons. Mice that are homozygous for a null mutation in the Ednrb gene are almost completely white and die as juveniles from megacolon. To determine when EDNRB signalling is required during embryogenesis, we have exploited the tetracycline-inducible system to generate strains of mice in which the endogenous Ednrb locus is under the control of the tetracycline-dependant transactivators tTa or rtTA. By using this system to express Ednrb at different stages of embryogenesis, we have determined that EDNRB is required during a restricted period of neural crest development between embryonic days 10 and 12.5. Moreover, our results imply that EDNRB is required for the migration of both melanoblasts and enteric neuroblasts.

Date: 1999
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DOI: 10.1038/990040

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