Breech-birth prions

James Hope ()
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James Hope: the Institute for Animal Health, Compton Laboratory, Compton

Nature, 1999, vol. 402, issue 6763, 737-739

Abstract: The neurodegeneration characteristic of transmissible spongiform encephalopathies is caused by changes in the metabolism of the prion protein (PrPC). In most cases, PrPC is converted to an abnormal protease-resistant form, PrPSc. But in some genetically inherited forms of the disease another abnormal form — CtmPrP — accumulates. A new study shows that CtmPrP may be a neurotoxic molecule that is common to both the genetic and acquired forms of prion diseases.

Date: 1999
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DOI: 10.1038/45413

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